We then quantified the density of c-Fos+ cells in the BC and observed that the WD group had a dramatic reduction in the density of c-Fos+ cells (Mdn = 104 cells/mm2 of BC region, IQR: 66–139) as compared with the control group (Mdn = 497 cells/mm2 of BC region, IQR: 381–597; U = 0, p < 0.001; Figures 1C,E). This evidence concerns the gene FOS and Wilson disease.