Furthermore, the involvement of the PI3K-III complex has been reported in the sorting of APP from the cell surface to endolysosomal and autophagic compartments (Swaminathan et al., 2016) and in the autophagic-lysosomal degradation of APP-CTFs in AD animal models (Wang et al., 2017; Yang et al., 2017). This evidence concerns the gene APP and Alzheimer disease.