For each irritative zone, we used histological biomarkers to evaluate anatomical (i.e., neurofilaments and neuronal cell density), functional (i.e., NR2B, GABAA and mGluR-5 receptors), and inflammatory (IL-1β, TNF-α, and HMGB1 signaling) abnormalities known to be involved in epileptogenesis in cases of FCD. This evidence concerns the gene HMGB1 and fleck corneal dystrophy.