Because E-Selectins bind sialyl Lewis X glycans enriched in neutrophils (Lasky, 1992) and the administration of sialyl Lewis X significantly decreases the recruitment of neutrophils to the ischemic region and decrease the infarct volume (Zhang et al., 1996), E-Selectins appear to be an important component of ischemia pathogenesis. The gene discussed is SELE; the disease is ischemia.