SIRT2 and Huntington disease: Süssmuth et al. (2015) failed to find any beneficial or adverse effects on any of the clinical outcome measures and they thought these results were related to the slow progression of HD. The Sirt2 inhibitor AK-7 ameliorates HD pathogenesis in R6/2 mice (Chopra et al., 2012). The bioactive sirt2 inhibitor MIND4 displays a similar role in ex vivo brain slices and in an in vivo Drosophila model of HD (Quinti et al., 2016). However, another group also found that inhibiting sirt2 had no effect on HD progression in the R6/2 mice model (Bobrowska et al., 2012).