The suppression of CREB-dependent transcription and the cell death induced by polyQ stretches are restored by co-expressing TAFII130 [TBP-associated factor (TAF)] (Shimohata et al., 2000) Furthermore, mHtt knockdown with shRNA prevents transcriptional repression of CREB in a HD cell model (Chaturvedi et al., 2012). This evidence concerns the gene TAF4 and Huntington disease.