MATR3 and amyotrophic lateral sclerosis: Although the mechanisms by which MATR3 might lead to ALS pathology remain to be elucidated, it appears that alterations in expression levels of MATR3 in the muscle and spinal cord might be critical for neuromuscular function and that dysregulation of its expression may underlie some aspects of neuromuscular dysfunction (Moloney et al., 2016; Rayaprolu et al., 2016).