Comparable changes of intrinsic pro- and anti-apoptotic signaling, including regulation of BCL2 family members and APAF1, were also shown during age-related hearing loss (ARHL) (Alam et al., 2001; Nevado et al., 2006; Tadros et al., 2008; Falah et al., 2016). The gene discussed is APAF1; the disease is presbycusis.