HRH3 and spindle cell hemangioma: Therefore, there is an indirect indication that histaminergic neurotransmission may have a significant role in SCH and that potent and selective H3R antagonists could lead to therapeutic improvements of cognitive symptoms associated with SCH and ASD (Witkin and Nelson, 2004; Esbenshade et al., 2008; von Coburg et al., 2009; Brown et al., 2013; Sadek et al., 2016).