HRH3 and Cognitive impairment: Moreover, a study considering the effectiveness of the non-imidazole H3R antagonist ABT-288 in the treatment of cognitive deficits linked with SCH revealed that schizophrenic features remained constant during the whole time period of the study, with acceptable safety, tolerability and pharmacokinetics profile of ABT-288 at a 15-fold higher dose and 12-fold higher exposures in subjects with SCH than previously observed in healthy volunteers (Coruzzi et al., 2012) (Hsieh et al., 2010).