OPTN mutations are linked to amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and normal-tension glaucoma; but it is also observed in protein inclusions present in Alzheimer's disease, Huntington's disease, and PD (Osawa et al., 2011; Ying and Yue, 2012). This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.