The report by Osawa et al. is very limited for its investigation of OPTN in PD; only two high magnification images are shown of what the authors report as an OPTN-positive Lewy body and Lewy neurite, but no comparison to a control patient was provided and no validation of the criteria for Lewy bodies and neurites (e.g., alpha-synuclein immunostain; Osawa et al., 2011). This evidence concerns the gene SNCA and Parkinson disease.