BRCA1 and breast cancer: In healthy women with BRCA1/2m, preventive salpingo-oophorectomy is recommended to reduce the risk of OC during the fifth decade of life.19,97,98 The effects of salpingo-oophorectomy on preventing BC in healthy premenopausal women with BRCA1m remains controversial,99,100 although the benefits in BRCA1/2m carriers are established.