BRCA1 and breast cancer: Talazoparib significantly prolonged PFS by blinded independent central review (8.6 months, 95% CI: 7.2–9.3 versus 5.6 months, 95% CI: 4.2–6.7; HR 0.542; P < 0.0001), and delayed time to deterioration in global health status/quality of life (HR 0.38; 95% CI: 0.26–0.55; P < 0.0001), compared with physician’s choice of therapy.64 Other PARPi that are currently being evaluated in phase II/III clinical studies in advanced cancers related to BRCA1/2m, including BC (rucaparib, veliparib, and niraparib) are described in Table 2.