BRCA1 and breast cancer: Interestingly, the reduction in risk associated with oophorectomy was greater in women with ER-negative BC (HR 0.07; 95% CI: 0.01–0.51) than in women with ER-positive BC (HR 0.76; 95% CI: 0.32–1.78).105 On the basis of these findings, the authors recommend that premenopausal women with newly diagnosed BC be tested for BRCA1/2m and, if mutation-positive, offered salpingo-oophorectomy as part of their treatment plan; however, this approach is controversial and not widely adopted.