POMT1 and muscular dystrophy-dystroglycanopathy, type A: Mutations in the POMT1 gene may cause severe, type A1 MDDGs (MDDGA1; OMIM #236670), including Walker-Warburg syndrome (WWS)10 and muscle-eye-brain disease (MEB)11, both of them coursing with significant impairments in the muscle, nervous system and eye.