ARHGAP15 and neoplasm: Subsequently, multivariate Cox regression analysis revealed that tumor size (hazard ratio, 3.07; 95% CI, 1.49–6.31; P = 0.002), metastasis (hazard ratio, 3.64; 95% CI, 1.67–7.92; P = 0.001) and ARHGAP15 expression (hazard ratio, 3.07; 95% CI, 1.57–6.01; P = 0.001) were independent prognostic factors for CRC (Table 2).