Previous two studies demonstrated that (1) 129 cytosolic DNA clones were identified from heart tissue isolated from IRF3 KO mice, while 137 cgDNA clones from TREX1/IRF3 double KO mice11 and (2) a total of 231 cytosolic DNA were cloned from tumor cells present in Eμ-Myc mice that is a model of Myc driven malignancy and genotoxic reagent Ara-C treated BC2 cells, a B cell lymphoma cell line derived from Eμ-Myc mice. This evidence concerns the gene IRF3 and neoplasm.