TREX1 prevents the L1 retrotransposon-induced DNA damage response, and mutations in RNases and a DNase, TREX1 has been linked with SLE, also known as Aicardi-Goutières syndrome62–65, and other autoimmune diseases such as Sjögren’s syndrome and systemic sclerosis65. The gene discussed is TREX1; the disease is Sjogren syndrome.