DDX39 is a DEAD box RNA helicase which unwind double-stranded RNA in an ATP-dependent manner, it interacts with HCC-1, U2AF65, REF2-1, TRF2, ALY, CIP29, and FUS/TLS to regulate transcription, splicing, RNA export, ribosome biogenesis, telomere protection and translation1–7, DDX39 also regulates tumor progression. The gene discussed is SARNP; the disease is neoplasm.