SNX10 and neoplasm: In the present study, ultra-high-performance liquid chromatography–quadrupole time of flight (UHPLC-QTOF)- and gas chromatography–mass spectrometry (GC-MS)-based untargeted metabolomics were used to analyze the metabolism alterations in the tumor tissues of wild-type (WT) and SNX10 knockout (KO) CRC male FVB mice, and the relation of amino-acid metabolism alteration and CRC cell proliferation and survival was investigated.