SNX10 and colorectal carcinoma: To further confirm the effect of SNX10 deficiency on CRC, we first measured the expression of SNX10 mRNA in NCM460 cell, which is a normal human colon mucosal epithelial cell line, and in three CRC cell lines HCT116, Caco-2, and SW480 cells (supplementary Fig. S1), and found that SNX10 mRNA level was decreased in CRC cells.