In contrast, the combination of Y27632 and Dox increased CD40 and CD86 expression as well as cross-presentation of OVA-derived peptide to MHC-I in DCs from tumour-draining LNs of B16F10-Ova tumour-bearing mice (Fig. 6c, d and Supplementary Fig. 20). This evidence concerns the gene CD40 and neoplasm.