ICD inducers can lead to increased expression of calreticulin, a prophagocytic signal for the uptake of tumour cells by DCs, on the surface of tumour cells and cause the release of ATP and high-mobility group box-1 (HMGB1) to promote DC maturation and cross-presentation, thereby promoting antitumour immunity20,33,34. The gene discussed is HMGB1; the disease is neoplasm.