Treatment of bone marrow-derived macrophages (BMDMs) or bone marrow-derived dendritic cells (BMDCs) with the ROCK inhibitor, Y27632, led to a significant increase in the engulfment of CT26.CL25 colon cancer cells and B16F10-Ova melanoma cells (Fig. 1a, c). Here, DDX53 is linked to colonic neoplasm.