Also during ischemia, Cx43 can be phosphorylated at S373, which activates a 14-3-3 mode-1 binding domain in Cx43; pS373 may disrupt Cx43/ZO-1 interaction, while the complex Cx43/14-3-3 facilitates ubiquitination, internalization and degradation of Cx43 [84]. The gene discussed is GJA1; the disease is ischemia.