The study that was conducted by Arici et al., 2009 [43] intimated the higher expression of Rb and cyclin D1 among nonneoplastic mucosa comprising dysplasia, intestinal metaplasia, atrophy, and gastritis to carcinoma, which indicates that the expression of pRb and cyclin D1 can occur in early stages of gastric carcinogenesis. This evidence concerns the gene RB1 and carcinoma.