ERBB2 and breast carcinoma: Amplification of this region was found in approximately 25% of breast tumors, which was associated with poor prognosis [6], implying the expression of KIAA0100 may be affected if such events occur; Also both ERRα and ER-α, were found to be recruited to the promoter region of KIAA0100 in the mouse model of ERBB2-initiated mammary tumorigenesis [7], implying the expression of KIAA0100 may be potentially up-regulated through these factors in breast cancer.