Because lack of toxicity on anchored cells by silencing KIAA0100 and the association between KIAA0100 and HSPA1A might be responsible for the anoikis resistance in suspended cells, specifically targeting to KIAA0100 or its interaction with HSPA1A might be able to sensitize the cancer cells that are in the process of metastasis to anoikis with less cytotoxicity effect to normal cells. This evidence concerns the gene HSPA1A and cancer.