However, because MDA-MB-231 cells were reported to be anoikis-resistant [33] and its cell aggregates in suspension are relatively loose compared to other breast cancer cell lines [22]; therefore in this case, this may suggest that the cell–cell adhesion/aggregation dependent survival may not be the key contributor for its anoikis resistance, and the initiation of the anoikis process but not the cell aggregation upon the silencing KIAA0100 might be the main driver for the loss of cell viability. This evidence concerns the gene BLTP2 and breast carcinoma.