APOA1 and apolipoprotein A-I deficiency: A total of 288 patients with “low HDL cholesterol” or “hypoalphalipoproteinemia” were sequenced with LipidSeq and screened for CNVs disrupting ABCA1, APOA1, and LCAT. Clinical and biochemical characteristics of the four patients identified as carriers for CNVs are shown in Table 1.