Furthermore, gene expression analyses showed the macrophage markers and their related inflammatory genes were suppressed in both adipose tissue (Fig. 14D to F) and the liver (Fig. 14G to I), and hepatic steatosis (Fig. 14J) was improved in the Wtap+/− recipient groups almost to the same extent as that observed in Wtap+/− mice. Here, WTAP is linked to fatty liver disease.