TP53 and bone metastasis: In the multiple logistic regression model (that included any parameters that were significant (P ≤ 0.05) in univariate analysis), the only variables that remained statistically associated with MET alterations were aberrations in TP53 (P = 0.001) and PTEN (P = 0.003) genes, as well as an increased incidence of bone metastasis (P = 0.007) (Table 2).