MTOR and melanoma: Liang et al. suggested that itraconazole may inhibit melanoma growth by blocking Hedgehog, Wnt, and phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K/mTOR) pathways, and showed that itraconazole prolonged survival in an in vivo xenograft mouse model of melanoma [12].