UBE2CP3 and hepatocellular carcinoma: Moreover, because our study was based on the co-culture system, adding ERK signalling inhibitors in the co-culture system will not only inhibited the ERK pathway in HCC cells but also reduce the activity of ERK in endothelial cells, a more appropriate experimental design is needed to study the function of UBE2CP3 when ERK signalling is inhibited.