Since VEGFA is one of the most important growth factors in angiogenesis and is the most obvious changing cytokine in UBE2CP3 overexpressing or knocking down HepG2 cells, we decided to investigate the role and the underlying mechanism of VEGFA in UBE2CP3 inducing angiogenesis in HCC. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.