Although we confirmed that UBE2CP3 may act as an oncogene to promote the secretion of VEGFA from HCC cells into the tumor microenvironment by activating the ERK/p70S6K/HIF-1α pathway and enhance tumor cell-induced angiogenesis, the underlying mechanism of how ECs respond to UBE2CP3 dysregulation in HCC cells is still unclear. The gene discussed is UBE2CP3; the disease is neoplasm.