PON1 and Insulin resistance: Changes in HDLs metabolism related to insulin resistance, glycation and depletion of apolipoprotein A-1 (apoA-1), modifications of other HDL-associated proteins such as paraoxonase-1 (PON-1) or oxidation of components of the HDL particles, and alterations of HDL proteome induced by chronic inflammation, all contribute to HDL dysfunction in diabetes [17].