It was reported that the decrease in expression of ADRB3 gene in VAT is associated with obesity, but not with the hypermethylation, demonstrating that the average levels of methylation of this gene in VAT was similar in slim individuals and with obesity from grade III [9], corroborating with the present study regarding the absence of difference of the methylation levels of the ADRB3 gene in leukocytes for different categories of BMI. Here, ADRB3 is linked to obesity due to melanocortin 4 receptor deficiency.