Then it triggered activation of the MAPK/ERK and PI3K/AKT/PKB signaling cascades as well as focal adhesion kinase in the adhesion/motility pathway in cell lines derived from adrenal, breast, cervical, and bladder cancer cells, as well as in modified mouse embryo fibroblasts [16, 37–39]. The gene discussed is AKT1; the disease is urinary bladder carcinoma.