An increasing number of female epilepsy patients with PCDH19 mutations have been reported over recent years, and the clinical spectrum of diseases associated with PCDH19 gene mutations has also expanded, including patients displaying focal or generalized seizures recurring in clusters or isolation with or without febrile trigger, ranging from mild to severe, with or without cognitive impairment, behavioural disturbance, and psychiatric symptoms [2, 4, 11, 13]. This evidence concerns the gene PCDH19 and Cognitive impairment.