In SCLC, we found those uniquely up-regulated TFs such as ASCL1, CENPB, HSF2, ZNF143 and down-regulated TFs such as STAT3, REST, NFKB1, different from those in LUAD and LUSC (Fig. 6a-b, Fig. 7c, Additional file 2: Table S1). This evidence concerns the gene REST and small cell lung carcinoma.