TF and cancer: To identify condition-specific regulation, we enforced three requirements (Methods): (i) co-expression between TF and predicted targets; (ii) co-expression among the predicted targets; (iii) differential regulation between cancer and normal tissue: the TF itself should at least be weakly deregulated and its targets should be distributed in the same direction as the TF, with an enrichment of 10 fold versus the opposite direction (Methods).