CCHCR1 and psoriasis: As CXCL8 (alias IL8) is involved in several signaling pathways that were highlighted in our expression data, as well as related to psoriasis, we validated its expression in the CCHCR1-HEK293 cell lines by qPCR; IL8 showed reduced expression in the Iso3 cell lines and upregulation in the Iso1cells, especially in Iso1Non-risk (Fig. 3c), as observed in RNAseq.