Pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1b, and stromal cell-derived factor 1 (CXCL 12), are produced excessively in the synovium of patients with RA, resulting in joint destruction, joint swelling, arthralgia, limited range of motion, and other complications [1,2,3]. Here, TNF is linked to rheumatoid arthritis.