We would underline that although recent evidence, in contrast to the past assumptions born with Otto Warburg’s work, indicates that cancer cells need functional mitochondria for their growth and survival [128], it has been demonstrated that tumors present at least an attenuated respiration driven by oncogenes, like Ras, or environmental conditions, like hypoxia or hypoxia-like hypoxia-inducible factor 1-alpha (HIF1α) overexpression [129,130,131,132,133]. The gene discussed is HIF1A; the disease is cancer.