The tumor cells release signaling proteins, such as vascular endothelial growth factor (VEGF), parathyroid hormone-related peptide (PTH-rp), bone morphogenic protein (BMP), and wingless (WNT), that stimulate the displacement of osteoblasts lining the bone surface, activating bone resorption by osteoclasts, and allowing tumor cell infiltration of the surface of the demineralized bone [17]. Here, PTHLH is linked to neoplasm.