High expression levels of lipogenic genes, such as acetyl-CoA carboxylase (ACC), FAS, lysophosphatidic acid acyltransferase (LPAAT), lipin, and DGAT enhance adipogenesis and obesity [10,11,12], whereas LPAATβ and lipin1-deficient cells do not express adipogenic marker proteins, such as C/EBPα and PPARγ, during adipocyte differentiation [13,14]. Here, MBOAT2 is linked to obesity due to melanocortin 4 receptor deficiency.