Moreover, P2X7R antagonists and Panx1 inhibitors, Erioglaucine and 10Panx peptide reverts neuropathic pain caused by oxaliplatin, while Panx1 inhibitors do not interfere the cytotoxic effect of oxaliplatin on human colon cancer cells HT-29 [187]. Here, PANX1 is linked to colonic neoplasm.