GJA1 and glioblastoma: Consistently, a recent study [178] showed that TMZ-resistant subline of U251 human GBM cells exhibited elevated Cx43 level compared to parental U251 cells, which was companied with increased EMT markers including vimentin, N-cadherin and β-catenin and decreased cell migration, monocyte adhesion and levels of vascular cell adhesion molecule (VCAM)-1.