Our current study showed that intraperitoneal administration of obestatin caused a reduction in the area of colonic damage, improved mucosal blood flow in the colon, and reduced white-blood-cell level, mucosal concentration of pro-inflammatory interleukin-1β, and mucosal activity of MPO, which accelerated the healing of TNBS-induced colitis. The gene discussed is MPO; the disease is colitis.