For example, Park et al. established recently, from a large-cohort study of 500 patient sera, a panel of two proteins, apolipoprotein A4 (APOA4) and tissue inhibitor of metalloproteinase-1 (TIMP1), that in combination with CA 19-9 detection, were able to discriminate pancreatitis from early PDAC [38]. Here, TIMP1 is linked to pancreatitis.