KRAS and familial pancreatic carcinoma: For example, Jorgensen’s team has recently demonstrated using murine Kras-mutated pancreatic cancer cells that oncogenic Kras signalling in tumour cells not only activates a cell-autonomous signalling network, but that it also activates the non-autonomous oncogenic signalling of stromal cells through a selective modification of their proteomes and their post-translationnal proteomes.