TRPC4 and renal carcinoma: However, the highest potencies were measured against heteromeric channels (formed by TRPC4–C1 or TRPC5–C1 concatemers; IC50 values of 33 pM and 199 pM, respectively) and (−)EA-activated, endogenous TRPC1:C4 channels in A498 renal carcinoma cells (IC50 = 49 pM).