In fact, the antioxidant and anti-inflammatory proprieties of HDL are thought to be regulated, at least in part, by upregulation of PPARγ/CD36 pathway [198,202] As already mentioned, MS patients display an adverse lipoprotein metabolism that may be associated with a dysfunctional pro-inflammatory HDL particle affecting PPARγ/CD36/Nrf2 signalling [203]. The gene discussed is PPARG; the disease is myeloid sarcoma.