Surprisingly, some of the downregulated genes have been related to pathogen dependent inflammatory pathways in lymphatic endothelial cells through caspase-1 (i.e., tlr1 [25], birc3 [26], serpinb9 [27]), somatostatin receptor expression in pulmonary tissues (sstr4 [28]), production of complement components (c3 [29]), neutrophil inflammatory response (aqp9 [30]) and leukemia progression (ephb4 [31]). The gene discussed is C3; the disease is leukemia.