The “INTERHEART” study, which involved participants from 52 countries, pointed out that in different parts of the world different risk factors were responsible for the development of myocardial infarction: factors which showed the strongest link with the development of myocardial infarction in Africa were diabetes and hypertension, in South America it was obesity and smoking, while the most important risk factors in Croatia were current smoking, diabetes, higher ApoB/Apo A-1 ratio, obesity and hypertension, while alcohol consumption was found to be protective [12]. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.