Type 1 BSCL occurs due to mutations in the gene AGPAT2 that encode 1-acylglycerol-3-phosphate O-acyltransferase 2 (1-AGPAT 2), while type 2 BSCL is caused by mutations in the gene BSCL2 that encode seipin [28,29]. The gene discussed is AGPAT2; the disease is Berardinelli-Seip congenital lipodystrophy.