Recently, we used CRISPR/Cas9 genome‐editing technology to establish human HCC cells knocked out for the ARID2 gene.50 ARID2 depletion attenuated nucleotide excision repair (NER) of DNA damage sites introduced by exposure to ultraviolet (UV) light as well as to chemical carcinogens, as XPG could not be accumulated without ARID2 (Figure 6A). The gene discussed is ERCC5; the disease is hepatocellular carcinoma.