MSH2 and pachyonychia congenita: Hereditary pancreatitis (SPINK1 mutations), hereditary breast ovarian syndrome (BRCA1 and BRCA2 mutations), Peutz‐Jeghers syndrome (STK11/LKB1 mutations), familial atypical multiple mole syndrome (CDKN2A mutations), Lynch syndrome (defects in MLH1, MSH2, MSH6, or PMS2), and familial adenomatous polyposis (APC mutations) have been associated with an increased risk of PC.32, 35, 36, 37, 38, 39 Identification of these cases should allow for focused screening in high‐risk populations.