In addition, the stress response to surgical insult results in insulin tolerance, and decreased pancreatic beta‐cell function causes hypo‐insulinemia, augmenting stress‐induced hyperglycemia.2 For the prevention of surgical site infections (SSI), appropriate perioperative insulin therapy is required in patients with hyperglycemia.3, 4, 5, 6, 7. This evidence concerns the gene INS and Hyperglycemia.