INS and Hypoglycemia: This recommendation has been challenged by recent studies suggesting that an even lower target BG is required to prevent SSI.12, 13, 14, 15, 16, 17, 18 The intensive insulin administration protocol (intensive protocol), however, leads to an increased risk of hypoglycemia, which, in turn, is associated with increased morbidity and mortality.19, 20 It seems that very strict glycemic control has modest benefits, with adverse effects often outweighing these advantages in critically ill patients.