The EGFR‐Ras‐Raf‐MEK‐ERK signaling pathway promotes cell proliferation, survival, and metastasis and is aberrantly activated by somatic mutations and gene amplifications in various cancers.30 Therefore, regulation of MAP2K1 expression by miR‐1271 may be important to GC development. The gene discussed is EGFR; the disease is gastric cancer.