AKT1 and cancer: It is well‐known that 14‐3‐3ε proteins participate in the cycle process via PI3K/AKT/FOXO and other signaling pathways, and cell cycle deregulation caused by changes in 14‐3‐3ε expression has been implicated in cancer formation.23 One published study showed that the ability of cdc25C to activate mitosis was inhibited in cells by knocking down filamin A expression.