We investigated the innate immunologic master player, thymic stromal lymphopoietin (TSLP), AMPs, and inflammatory signals in HEKs treated with heat-inactivated S. aureus (HKSA) in vitro, and in 2,4-dinitrochlorobenzene- (DNCB-) induced AD-like skin lesions in Nc/Nga mice. Here, TSLP is linked to Alzheimer disease.