To further explore the mechanisms by which TRIM24 promote the proliferation of HNSCC cells, we investigated if TRIM24 could serve as a transcriptional activator which activates cyclin D. From previous report [14], we noticed ChIP-seq results of TRIM24 in Lncap and K562 cells (Encode project), which revealed that there were potential TRIM24 binding sites in Cyclin D1 promoter, including 5734, 2166, and 64 upstream from the transcription start site. The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.