Studies have indicated that increased TGF-β signaling after stroke is neuroprotective and likely to be an important target for future stroke therapies [19, 20]. WNT signaling can enhance neurogenesis and improve neurological function after ischemic injury [21, 22]; it also has anti-inflammatory effects [23] and is neuroprotective in stroke [24]. Here, TGFB1 is linked to stroke disorder.