The family of GPCRs involved in the c-AMP/PKA pathway is known to provide neuroprotection against ischemic injury [35] and activate CREB for neuronal cell-survival after ischemia injury [36]. Alpha-MSH confers anti-inflammatory [37], antioxidative, and antiapoptotic [38] effects after ischemia. The gene discussed is CREB1; the disease is ischemia.